Beilstein J. Org. Chem.2013,9, 900–907, doi:10.3762/bjoc.9.103
may allow for better fundamental understanding of this highly complex biochemical signaling network and could advance future therapeutic translation toward the clinical setting.
Keywords: ML029; ML130; ML146; ML236; ML237; Introduction
The Molecular Libraries Network was established in 2005 as an
probe, including their general physicochemical and pharmacological properties, are summarized in this report.
Results and Discussion
Phenotypic screening for noncanonical NF-κB pathway selective inhibitors of IL-8 production in HEK 293, HEK 293T (ML029) and 697 pre-B cells (ML236 and ML237): Most
other NF-κB activation pathways such as those including the cytosolic proteins CARMA1, Bcl-10, MALT1, TRAF6 and Ubc13 [8].
The first probe identified within this series was the benzimidazole ML029 (4), which exhibited an IC50 of 0.07 μM in the HEK 293 cell assay with corresponding well-defined structure