Melifoliox B, a novel phloroglucin derivative isolated from Melicope barbigera (Rutaceae) and synthesis of new oxidation products from melifoliones A and B

• Horst Weber,
• Kim-Thao Tran-Cong,
• Bernhard Mayer,
• Guido J. Reiss,
• Iryna S. Konovalova,
• Marc S. Appelhans,
• Kenneth R. Wood and
• Claus M. Passreiter

Beilstein J. Org. Chem. 2026, 22, 535–546, doi:10.3762/bjoc.22.39

• been described in the literature. Keywords: Melicope barbigera; Melifoliones A and B; new heterocyclic ring systems; new natural compounds; para-quinols; phenol oxidation; Introduction The genus Melicope is a member of the Rutaceae (Citrus family) and contains more than 200 species distributed in the

• acylated phenol into a furanone ring. The result of this work was not expected and totally surprising. We not only present melifoliox B (4) as a new natural product but also found two new synthetic compounds with new heterocyclic ring systems as oxidation products of melifoliones A and B. Both structures