Copper-catalyzed enantioselective conjugate addition of organometallic reagents to challenging Michael acceptors

• Delphine Pichon,
• Jennifer Morvan,
• Christophe Crévisy and
• Marc Mauduit

Beilstein J. Org. Chem. 2020, 16, 212–232, doi:10.3762/bjoc.16.24

• accomplished in this stimulating field. Keywords: acylimidazole; N-acyloxazolidinone; N-acylpyrrole; N-acylpyrrolidinone; aldehyde; amide; copper catalysis; electron-deficient alkenes; enantioselective conjugate addition; Michael acceptor; thioester; Introduction Generating high molecular complexity and

• reagents to α,β-unsaturated amides. Cu/Josiphos (L9)-catalyzed ECA of Grignard reagents to polyunsaturated amides. Cu-catalyzed ECA of trimethylaluminium to N-acylpyrrole derivatives. Acknowledgements We are grateful to the Ecole Nationale Supérieure de Chimie de Rennes (ENSCR) and the Centre National de