Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

• Chelsea L. Rintelmann,
• Tara Grinnage-Pulley,
• Kathleen Ross,
• Daniel E. K. Kabotso,
• Angela Toepp,
• Anne Cowell,
• Christine Petersen,
• Balaji Narasimhan and
• Nicola Pohl

Beilstein J. Org. Chem. 2019, 15, 623–632, doi:10.3762/bjoc.15.58

• recognition by pathogen-recognition receptors during L. major-induced leishmaniasis. Keywords: adjuvant; carbohydrates; L. major; microparticle; PAMP; Introduction Recognition of parasite cell surface molecules by host immune cells initiates the first step in the immune response [1][2]. The host’s immune

• mechanisms of L. major immune suppression and evasion. The fluorescent-tagged pathogen-associated oligosaccharide probe was synthesized through orthogonal conjugation for ease of attachment to bioerodible microparticles. The PAMP carbohydrate 16 was further synthesized through iterative glycosylation and

Aminosugar-based immunomodulator lipid A: synthetic approaches

• Alla Zamyatina

Beilstein J. Org. Chem. 2018, 14, 25–53, doi:10.3762/bjoc.14.3

• cardiovascular disorders. The LPS of P. gingivalis, and particularly its lipid A, is recognized as major PAMP implicated in the pathogenesis of the periodontal disease. P. gingivalis LPS has been shown to stimulate the persistent production of IL-1, IL-6, and IL-8 in gingival fibroblasts which are thought to