Beilstein J. Org. Chem.2021,17, 2939–2949, doi:10.3762/bjoc.17.203
metabolites of Pseudosporangium sp. RD062863, a strain available at the culture collection of the Biological Resource Center, National Institute of Technology and Evaluation (NBRC) [20], and discovered a novel cyclopeptide pseudosporamide along with three new oligomycin-class polyketide [21]. In addition, the
Beilstein J. Org. Chem.2020,16, 1100–1110, doi:10.3762/bjoc.16.97
mining indicated that members of the underexplored genus Pseudosporangium, from which no secondary metabolites have been reported to date, may harbor the biosynthetic machinery for the formation of novel natural products. The strain RD062863, that is available at a public culture collection, was obtained
discovery of new natural products.
Keywords: DFT-based calculation; oligomycin; peptide; polyketides; Pseudosporangium; rare actinomycetes; Introduction
Microbial secondary metabolites have been used as therapeutic drugs [1], veterinary medicines [2], agrochemicals [3], food preservatives/colorings [4][5
over 400 natural products [15], no secondary metabolites are reported from at least 24 genera. One such genus, Pseudosporangium, originally discovered from a sandy soil in Bangladesh in 2008 by Takahashi and co-workers [16], appeared promising, as genome mining in the draft sequence of P. ferrungineum
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Graphical Abstract
Figure 1:
Structures of pseudosporamide (1) and pseudosporamicins A–C (2–4).