Synthesis of coumarin or ferrocene labeled nucleosides via Staudinger ligation

• Ivana Kosiova,
• Andrea Janicova and
• Pavol Kois

Beilstein J. Org. Chem. 2006, 2, No. 23, doi:10.1186/1860-5397-2-23

• synthesised from 5'-tosylated intermediates, [36] whilst 3'-azido-3'-deoxythymidine 6 was prepared via a Mitsunobu type reaction. [37] Staudinger reaction of azidonucleosides 3–6 with triphenylphosphine led to iminophosphorane intermediates 7–10, which reacted subsequently with active esters of coumarin-4