Z-Selective semihydrogenation of alkynes via Ni/Lewis acid synergistic catalyzed system using DMF as hydrogen source and solvent

• Lei Kang,
• Haifeng Gao and
• Luo Yang

Beilstein J. Org. Chem. 2026, 22, 1004–1012, doi:10.3762/bjoc.22.79

• dual-catalytic system has been developed for the Z-selective semihydrogenation of alkynes. Utilizing DMF as both the hydrogen donor and reaction medium, this method affords Z-alkenes in high yield with excellent stereoselectivity under mild conditions. The protocol employs cost-effective and readily

• available catalysts, and demonstrates broad applicability across a wide range of substrates. Keywords: alkynes; DMF; Ni/Lewis acid catalysis; Z-selective semihydrogenation; Introduction Z-Olefins represent important structural units in natural products, pharmaceuticals, and functional materials, making

• , 24 h), we evaluated the generality of this Z-selective semihydrogenation with various internal alkynes (Scheme 1). The system proved broadly effective for both symmetrical and unsymmetrical diarylacetylenes 1a–p. Substrates bearing electron-donating groups (methyl 2b, 2c, 2e; methoxy 2d), electron

Electrochemical reduction of unsaturated carbon–carbon bonds via 3d transition-metal catalysis

• Geon Kang,
• Minki Jeon,
• Pooja Kumari Jat,
• Cheoljae Kim and
• Isaac Choi

Beilstein J. Org. Chem. 2026, 22, 955–981, doi:10.3762/bjoc.22.75

• group reported a voltage-controlled tandem electrocatalytic Z-selective semihydrogenation, in which cobaltocene operates as a cobalt redox mediator 3 in concert with a cobalt catalyst 9 (Scheme 4A) [97]. This strategy enables the selective hydrogenation of activated alkynes to cis-alkenes while

• catalysis. Cobalt-catalyzed e-HAT for the reduction of alkynes. Dual cobalt catalyses for Z-selective semihydrogenation of alkynes. Electrochemical cobalt-catalyzed semideuteration of alkynes. Electrochemical cobalt catalysis for E-selective semihydrogenation of alkynes. Concerted proton–electron transfer