Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis

• Stephan Klopries,
• Uschi Sundermann and
• Frank Schulz

Beilstein J. Org. Chem. 2013, 9, 664–674, doi:10.3762/bjoc.9.75

• for actinomycetes in contrast to standard plate covers with air-permeable foils. A 3 mL volume of TSB was inoculated with a 0.5 cm × 0.5 cm agar slice of a sporulating petri-dish culture and cultivated for 48 h at 30 °C. The main culture consisting of 3 mL SM3 [45] complemented with feeding-buffer

Novel fatty acid methyl esters from the actinomycete Micromonospora aurantiaca

• Jeroen S. Dickschat,
• Hilke Bruns and
• Ramona Riclea

Beilstein J. Org. Chem. 2011, 7, 1697–1712, doi:10.3762/bjoc.7.200

• for internal methyl branches in various chain positions, while the methyl ester function is derived from S-adenosyl methionine (SAM). Keywords: actinomycetes; FAMEs; fatty acid biosynthesis; GC–MS; volatiles; Introduction Lipids in general, and particularly fatty acids (FAs), belong to the most

• -methylpentanoate (5), methyl isocaproate (6), and methyl 3-methylpentanoate (7) were found in actinomycetes [11][12]. Methyl 9-methyldecanoate (8) is released by the myxobacterium Stigmatella aurantiaca DW4/3-1 [13]. A complex mixture of several methyl 2-methylalkanoates (9–26) was recently reported from the

• gliding bacterium Chitinophaga Fx7914 [14]. Some α,β-unsaturated FAMEs have also been described, such as methyl 4-methylpent-2-enoate (27), methyl tiglate (28), and methyl 3-methylcrotonate (29) from actinomycetes [12], and various methyl 2-methylalk-2-enoates (30–43) from Chitinophaga [14]. The proposed

Phaeochromycins F–H, three new polyketide metabolites from Streptomyces sp. DSS-18

• Jian Li,
• Chun-Hua Lu,
• Bao-Bing Zhao,
• Zhong-Hui Zheng and
• Yue-Mao Shen

Beilstein J. Org. Chem. 2008, 4, No. 46, doi:10.3762/bjoc.4.46

• ; structure determination; Introduction Marine microorganisms are widely recognized as rich sources of novel natural products [1][2]. In recent years, numerous novel compounds discovered from marine actinomycetes have been reported [3][4][5]. During the course of our search for biologically active substances

• from marine derived actinomycetes, a strain of the genus Streptomyces was isolated from deep sediment collected from the west Pacific. Herein, we report the isolation and structure determination and biological properties of three new polyketides, namely phaeochromycins F (1), G (2) and H (3), from