Synthesis of modified cyclic and acyclic dextrins and comparison of their complexation ability

• Kata Tuza,
• László Jicsinszky,
• Tamás Sohajda,
• István Puskás and
• Éva Fenyvesi

Beilstein J. Org. Chem. 2014, 10, 2836–2843, doi:10.3762/bjoc.10.301

• the guests. This was explained by the enhanced flexibility of the non-closed rings. Even the signs of enantiorecognition were observed for the chloropheniramine/hydroxypropyl maltohexaose system. Further studies are planned to help the deeper understanding of the interactions. Keywords: acyclodextrin

• number of glucopyranose units. Unlike CDs, the number of the glucose units might not be of primary importance in the case of ibuprofen/acyclodextrin interactions. An even more surprising finding was observed for nateglinide, as the highest interaction affinity was determined with the G6 acyclic dextrin

• filtrates were treated with strong ion exchanger and charcoal. Evaporation of solvents yielded 0.1/0.1/0.1 g of solids, respectively (~55%). HP-(DS~4)-cyclodextrins: Identical synthetic methods were used, as for the preparation of the corresponding acyclodextrin derivatives. DS = 4 was calculated based on