Beilstein J. Org. Chem.2023,19, 998–1007, doi:10.3762/bjoc.19.75
, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China 10.3762/bjoc.19.75 Abstract Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including
revealed the structure–activity relationships (SAR).
Keywords: agarwood; Aquilaria sinensis; SAR studies; sesquiterpenoids; Introduction
Agarwood is the resinous wood of the Aquilaria species of the Thymelaeaceae family [1]. It is a precious traditional Chinese medicinal material and a kind of natural
fragrance that is widely distributed in China, India, the Middle East, and Southeast Asia [2]. Agarwood has been considered to play an important role in both traditional Chinese medicine and Ayurvedic medicine in the treatment of stomach disorders, coughs, asthma, sedation, analgesia, and antiemetic [3][4