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Search for "alkylators" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

An overview of recent advances in duplex DNA recognition by small molecules

Sayantan Bhaduri,
Nihar Ranjan and
Dev P. Arya

Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93

the past few years. Keywords: alkylators; antibiotic; anticancer; antineoplastic; antiproliferative; DNA recognition; groove binders; hairpin polyamides; Hoechst 33258; intercalators; Review 1. Introduction DNA is one of the central components of cellular machinery and storage unit of genetic

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Graphical Abstract

Figure 1: A figure showing the hydrogen bonding patterns observed in (a) duplex (b) triplex and (c) quadruple...

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Figure 2: (a) Portions of MATα1–MATα2 are shown contacting the minor groove of the DNA substrate. Key arginin...

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Figure 3: Chemical structures of naturally occurring and synthetic hybrid minor groove binders.

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Figure 4: Synthetic structural analogs of distamycin A by replacing one or more pyrrole rings with other hete...

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Figure 5: Pictorial representation of the binding model of pyrrole–imidazole (Py/Im) polyamides based on the ...

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Figure 6: Chemical structures of synthetic “hairpin” pyrrole–imidazole (Py/Im) conjugates.

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Figure 7: (a) Minor groove complex formation between DNA duplex and 8-ring cyclic Py/Im polyamide (conjugate ...

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Figure 8: Telomere-targeting tandem hairpin Py/Im polyamides 23 and 24 capable of recognizing >10 base pairs; ...

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Figure 9: Representative examples of recently developed DNA minor groove binders.

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Figure 10: Chemical structures of bisbenzamidazoles Hoechst 33258 and 33342 and their synthetic structural ana...

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Figure 11: Chemical structures of bisamidines such as diminazene, DAPI, pentamidine and their synthetic struct...

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Figure 12: Representative examples of recently developed bisamidine derivatives.

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Figure 13: Chemical structures of chromomycin, mithramycin and their synthetic structural analogs 91 and 92.

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Figure 14: Chemical structures of well-known naturally occurring DNA binding intercalators.

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Figure 15: Naturally occurring indolocarbazole rebeccamycin and its synthetic analogs.

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Figure 16: Representative examples of naturally occurring and synthetic derivatives of DNA intercalating agent...

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Figure 17: Several recent synthetic varieties of DNA intercalators.

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Figure 18: Aminoglycoside (neomycin)–Hoechst 33258/intercalator conjugates.

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Figure 19: Chemical structures of triazole linked neomycin dimers and neomycin–bisbenzimidazole conjugates.

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Figure 20: Representative examples of naturally occurring and synthetic analogs of DNA binding alkylating agen...

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Figure 21: Chemical structures of naturally occurring and synthetic analogs of pyrrolobenzodiazepines.

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Review

Published 16 May 2018

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