Beilstein J. Org. Chem.2020,16, 2100–2107, doi:10.3762/bjoc.16.177
-cho, Chikusa-ku, Nagoya, Aichi, Japan 10.3762/bjoc.16.177 Abstract Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute
configurations were determined using the modified Mosher’s method and through comparisons of experimental and calculated electronic circular dichroism data. In addition, muyocopronone B (2) was found to exhibit a weak antibacterial activity against some Gram-positive bacteria.
Keywords: azaphilones; endophytic
fungus; modified Mosher’s method; Muyocopron laterale; polyketides; Introduction
Azaphilones, which are a class of fungal polyketides with diverse structures, have received growing attention due to their various biological activities, such as the inhibition of some protein–protein interactions [1][2