Beilstein J. Org. Chem.2020,16, 3008–3014, doi:10.3762/bjoc.16.250
synthesis of biarenes has been developed. The approach is based on the photoextrusion of a phosphate moiety occurring upon irradiation of biaryl- and triaryl phosphates. The reaction involves an exciplex as the intermediate and it is especially suitable for the preparation of electron-rich biarenes
.
Keywords: aryl phosphates; biarenes; metal-free synthesis; photochemistry; photoextrusion; Introduction
It is difficult to overestimate the importance of aromatics in drug development. Indeed, introducing an aromatic or a heteroaromatic ring, most often a (substituted) phenyl ring, into a biologically
the presence of increasing amounts of TFE (up to 20% v/v, continuous line).
Synthesis of biarenes via a) photogenerated triplet aryl cations and aryl radicals (PC = photocatalyst), b) intramolecular free radical ipso substitution, c) thermally catalyzed extrusion of CO and SO2, d) photoinduced
PDF
Graphical Abstract
Scheme 1:
Synthesis of biarenes via a) photogenerated triplet aryl cations and aryl radicals (PC = photocatal...