A Streptomyces P450 enzyme dimerizes isoflavones from plants

• Run-Zhou Liu,
• Shanchong Chen and
• Lihan Zhang

Beilstein J. Org. Chem. 2022, 18, 1107–1115, doi:10.3762/bjoc.18.113

• seen in vinblastine [2], julichrome [3], himastatin [4], and biflavone [5]. However, the structural complexity of the dimeric natural products has hampered synthetic chemistry approaches towards these molecules, since chemo-, regio-, and atroposelective formation of the biaryl linkage remains highly

Total synthesis of ochnaflavone

• Monica M. Ndoile and
• Fanie R. van Heerden

Beilstein J. Org. Chem. 2013, 9, 1346–1351, doi:10.3762/bjoc.9.152

• Monica M. Ndoile Fanie R. van Heerden School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, Pietermaritzburg, South Africa 10.3762/bjoc.9.152 Abstract The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin

• the oxidative cyclization to form ochnaflavone were established. Keywords: biflavone; diaryl ether; natural products; nucleophilic aromatic substitution; ochnaflavone; tetrahydroochnaflavone; Introduction Biflavonoids are a class of compounds that are receiving increasing attention because of their

• and the ring A of the other moiety (AB type), between two A rings (AA type) or between the two C rings (3,3''-CC type), but the most rare biflavonoids are the ones with the interflavonoid linkage between the two B rings. Ochnaflavone (1) (Figure 1) is a biflavone with an ether linkage between the B