Beilstein J. Org. Chem.2006,2, No. 23, doi:10.1186/1860-5397-2-23
gives iminophosphoranes which can react with almost any kind of electrophilic reagent, e.g. aldehydes/ketones to form imines or esters to form amides. This so-called Staudinger ligation has been employed in a wide range of applications as a general tool for bioconjugation including specific labeling of
electrophiles, such as esters, can undergo reaction with iminophosphorane to form amides, especially if the electrophilic attack proceeds in an intramolecular fashion. [17][18][19][20][21] This so-called Staudinger ligation has been employed in a wide range of applications as a general tool for bioconjugation