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Search for "biofilm" in Full Text gives 33 result(s) in Beilstein Journal of Organic Chemistry.
Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens
Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273
- medium. The authors prove that the cross-linked CDs regulate the release through an affinity-driven mechanism (see above). Moreover, the antiseptic-loaded gauzes were able to inhibit biofilm formation of S. aureus when applied in early stages of biofilm formation. Heavy-metal biocides i) Silver
Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators
Beilstein J. Org. Chem. 2014, 10, 2539–2549, doi:10.3762/bjoc.10.265
- target genes important for phenotype expression (e.g., biofilm formation, bioluminescence, virulence expression, etc.) in a population density dependent manner [2]. The importance of QS for virulence development in pathogenic bacteria nowadays is obvious [3]. Therefore, quorum sensing modulation is seen
Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation
Beilstein J. Org. Chem. 2014, 10, 1981–1990, doi:10.3762/bjoc.10.206
- glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows
- good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation. Keywords: antibiotic; biofilm; glycocluster; lectin; multivalency effect; multivalent glycosystems; Introduction Pseudomonas aeruginosa (PA
- particular due to the physical barrier created by surface-attached biofilms, thus limiting antibiotic penetration [4][5][6]. A challenging and useful task is therefore to develop novel strategies against PA colonies at this late stage of virulence. Among recent approaches, targeting biofilm formation or
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans
Beilstein J. Org. Chem. 2013, 9, 1501–1507, doi:10.3762/bjoc.9.171
- against diverse mechanisms of fluconazole resistance, including biofilm formation, drug-target mutations, and efflux-pump amplification. Conclusion High-throughput screening of 300,000 compounds from the NIH’s MLSMR collection identified several substances that potentiate the effect of fluconazole in
Synthetic glycopeptides and glycoproteins with applications in biological research
Beilstein J. Org. Chem. 2012, 8, 804–818, doi:10.3762/bjoc.8.90
- airways [106][143]. Previously, it was found that the LecB protein was important for biofilm formation [144][145][146]. In the screening for LecB inhibitors, one glycopeptide dendrimer, FD2 49 (C-FucLysProLeu)4(LysPheLysIle)2LysHisIleNH2, showed particularly strong LecB inhibition (FD2 IC50 = 0.14 μM and
- L-fucose IC50 = 11 μM) [106]. The glycopeptide dendrimer was able to completely inhibit P. aeruginosa biofilm formation at a concentration of 50 μM and established biofilms from wild-type strain and clinical isolates could be completely dispersed. In a later study, analogues of FD2 49 were prepared
- ; in one of them the L-amino acids were replaced by D-amino acids (D-FD2, 51) to avoid proteolytic cleavage of the peptide construct [147]. Interestingly, it was found that the D-FD2 51 glycopeptide dendrimer showed a slightly weaker binding affinity to LecB, but the P. aeruginosa biofilm inhibitory
Volatile organic compounds produced by the phytopathogenic bacterium Xanthomonas campestris pv. vesicatoria 85-10
Beilstein J. Org. Chem. 2012, 8, 579–596, doi:10.3762/bjoc.8.65
- ][41]. Dodecan-2-one (38) was found among the volatiles of Serratia strains [41], and decan-2-one (28) was released by an epilithic cyanobacterial biofilm of Rivularia sp. and Calothrix parietina [42]. The main component among the volatile compounds released by X. c. pv. vesicatoria 85-10, namely 10
Coupled chemo(enzymatic) reactions in continuous flow
Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169
- example fermentative production of ethanol, butanol, lactic acid, acetic acid/vinegar, succinic acid and fumaric acid in continuously operated biofilm reactors containing thick layers of microbial cells [44]. In this section only a few representative examples are reviewed, which illustrate the potential
- biofilm membrane reactor (Scheme 24) [52][53]. Cells of Pseudomonas sp. were grown in a biofilm attached to the inner surface of a silicon tube, through which a nutrient solution was constantly pumped. In a specially designed hermetic reaction compartment the tube was partially submerged into liquid 73
- , which slowly diffused through the tube wall to the biofilm. Inside the tube 73 was enantioselectively oxidized to (S)-74, which in turn diffused back into the reaction compartment. The cofactor FADH2 required for the oxidation was regenerated during metabolic activity of the cells. Due to diffusion
A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH
Beilstein J. Org. Chem. 2010, 6, 801–809, doi:10.3762/bjoc.6.90
- persistent biofilms. In all cases of bacterial adhesion and of biofilm formation severe health problems can result for the host organism [1][2]. A number of microbial adhesins are known, that co-operate in the adhesion process [3], such as the fimbriae, which are long filamentous adhesive organells on the
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