Beilstein J. Org. Chem.2022,18, 1524–1531, doi:10.3762/bjoc.18.161
the same region occupied by crystallographic ligands in their complex with IMPDH. The results obtained in this study suggest that compound 8 might be a new anti-RSV candidate.
Keywords: antiviral; betulinic acid; bioisosterism; respiratory syncytial virus; triterpene; ursolic acid; Introduction
scenario, here, we report our aims to develop new triterpene derivatives using a bioisosterism approach with RBV as an IMPDH inhibitor and anti-RSV agent.
Results and Discussion
Chemistry
In this study, we synthesized two new heterocycle-modified triterpene derivatives (compounds 7 and 8) with a 1,2,3
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Graphical Abstract
Figure 1:
Structures of RBV, betulinic acid (1), and ursolic acid (2).
Beilstein J. Org. Chem.2017,13, 2561–2568, doi:10.3762/bjoc.13.252
derivatives, there is great interest in imidazo[1,5-annelated]diazines due to their diverse pharmacological actions and bioisosterism with imidazo[4,5-d]pyrimidines (purines). The presence of a bridgehead nitrogen atom is a common structural motif of these heterocyclic systems. For example, compounds with the
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Graphical Abstract
Scheme 1:
Intramolecular cyclization of 3-(aminomethyl)pyridazines and related compounds (route A). Condition...