Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum

• Naoya Oku,
• Miyako Matsumoto,
• Kohsuke Yonejima,
• Keijiroh Tansei and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2014, 10, 1808–1816, doi:10.3762/bjoc.10.190

• C12, the more abundant 3 was condensed either with (S)- or (R)-α-methoxyphenylacetic acid (MPA) [15] to give bis-MPA esters 3a and 3b. The δΔ values for the 2-en-1,4-diol moiety do not hold a diagnostic value because this region is under the influence of overlapping anisotropic effects by the flanking

Bifunctional dendrons for multiple carbohydrate presentation via carbonyl chemistry

• Davide Bini,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2014, 10, 1686–1691, doi:10.3762/bjoc.10.177

• carbonyl group at the termini has been carried out. The carbonyl group has been exploited for the multivalent conjugation to a sample saccharide by reductive amination and alkoxyamine conjugation. Keywords: bis-MPA; carbohydrates; dendrons; levulinic acid; multivalency; multivalent glycosystems

• reactions with levulinic acid (15). Building blocks 13 and 14 were synthesized starting from bis-(hydroxymethyl)propionic acid (bis-MPA) and bromo-1-pentene [11] in one and four steps, respectively. L-Fucose derivatives synthesis α-L-(2-Aminoethyl) fucopyranoside (4) and α-O-L-fucopyranosyloxyamine (5) were