Beilstein J. Org. Chem.2012,8, 804–818, doi:10.3762/bjoc.8.90
water-soluble radical initiator VA-044 [73]. The radical-induced desulfurization method has also been applied in the total synthesis of an EPO glycoprotein analogue [69].
Another promising path to prepare homogenous glycoproteins is represented by chemoenzymaticsynthesis. Both glycosyltransferases and
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Graphical Abstract
Figure 1:
Tumor-associated glycosylation on MUC1 tandem repeat peptides.
Beilstein J. Org. Chem.2010,6, No. 18, doi:10.3762/bjoc.6.18
human milk oligosaccharides are considered as soluble receptor analogues of epithelial cell surfaces [6].
Results and Discussion
Previously, we reported the chemoenzymaticsynthesis of the 3-sialylated lactosamine derivative 3 obtained by the enzymatic β-galactosylation of the 2-azidothioglucoside with