Novel macrocycles: from synthesis to supramolecular function

• Veronica Iuliano,
• Carmen Talotta,
• Margherita De Rosa,
• Paolo Della Sala,
• Konrad Tiefenbacher,
• Pablo Ballester and
• Carmine Gaeta

Beilstein J. Org. Chem. 2026, 22, 982–985, doi:10.3762/bjoc.22.76

• peptide-functionalized supramolecular tweezers was developed by Schrader and Vetter [42] to target survivin, a key component of the chromosomal passenger complex (CPC). These receptors were designed to interfere with the recognition of phosphorylated histone H3 by the survivin BIR domain, displaying high

Molecular tweezer–peptide conjugates disrupt the protein–protein interaction between survivin and histone H3 essential in mitosis

• Catherine Gsell,
• Philipp Rebmann,
• Karina Opara,
• Christine Beuck,
• Peter Bayer,
• David Bier,
• Ingrid R. Vetter and
• Thomas Schrader

Beilstein J. Org. Chem. 2026, 22, 557–567, doi:10.3762/bjoc.22.41

• , Otto-Hahn-Straße 11, 44227 Dortmund, Germany 10.3762/bjoc.22.41 Abstract Peptide-modified supramolecular tweezers, a promising new class of chemical tools, were designed and employed to inhibit the interaction of the BIR domain of human survivin, a member of the chromosomal passenger complex (CPC

• Pro26, corresponding to a previously unknown binding mode. Guided by the accessibility of survivin’s lysine residues in the CPC, a number of new promising peptide tweezers was synthesized, able to connect both binding sites on the protein. Keywords: click reaction; chromosomal passenger complex

• cell division, this kinetochore interacts with a smaller ensemble, the chromosomal passenger complex (CPC) that constitutes an abundant component of the inner centromere [2][3]. The CPC itself is formed inside the cell nucleus and consists of the four proteins survivin, borealin, INCENP (inner

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

• Silke Felix,
• Louis P. Sandjo,
• Till Opatz and
• Gerhard Erkel

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

• controlling cell division. In normal differentiated tissues the expression of survivin is cell cycle-regulated with an expression maximum in G2/M phase [7]. During mitosis, survivin is associated in the chromosomal passenger complex (CPC), a multi-protein complex, including the proteins Aurora B kinase, inner