Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• Xiao Yin Mak Paola Laurino Peter H. Seeberger Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, D-14424 Potsdam, Germany 10.3762/bjoc.5.19 Abstract An overview of asymmetric synthesis in continuous flow and microreactors is presented in

• this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed. Keywords: asymmetric catalysis; biocatalysis; continuous flow; microreactors; solid phase synthesis; Introduction While many technological advancements have been made over

• reproducibility due to the precise control over reaction conditions in these devices. Continuous flow technology has excellent potential for the integration of a high level of automation and for the incorporation of on-demand reaction analysis. This can be advantageous for applications such as high-throughput

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactor

• Andrew Bogdan and
• D. Tyler McQuade

Beilstein J. Org. Chem. 2009, 5, No. 17, doi:10.3762/bjoc.5.17

• potential as continuous flow processes. Realizing this, we developed a catalytic packed-bed microreactor that could be used for the continuous flow oxidation of alcohols to aldehydes or ketones. Oxidations that do not require transition metal catalysts are particularly appealing since there is neither