Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles

• Kathrin Fiege,
• Heinrich Lünsdorf,
• Sevil Atarijabarzadeh and
• Petra Mischnick

Beilstein J. Org. Chem. 2012, 8, 551–566, doi:10.3762/bjoc.8.63

• spectroscopy (PEELS). Keywords: cyanoethyldextran; cyanoethylpullulan; ferromagnetic nanoparticles; glycan nanostructures; substitution pattern; Introduction Cyanoethylation has been widely applied to polysaccharides, e.g., to cellulose [1], inulin [2], and starch [3]. Onda reported on cyanoethylation of

• -substitution at terminal residues, eight different constituents are expected for cyanoethyldextran: unsubstituted (s0), monosubstituted at position 2, 3, or 4 (s2, s3, s4), disubstituted at positions 2,3, 2,4, or 3,4 (s23, s24, s34), and 2,3,4-tri-O-substituted glucose (s234). For pullulan, 6-, 2,6-, 3,6-, and

• stabilization. At pH 2 the iron oxide dispersion is stable for several months without precipitation. After the dialysis process of the high-DS cyanoethyldextran and pullulan (20 mg, CED-3, DSGC = 2.40; CEP-3, DSGC = 2.42) the hydrodynamic diameter of the particles was determined by DLS. Additionally, scanning