Beilstein J. Org. Chem.2017,13, 564–570, doi:10.3762/bjoc.13.55
)anthraquinones with a series of cations demonstrated their high binding affinity to Cu2+, Al3+, and Cr3+.
Keywords: amination; aminocholanes; bile acids; cation complexation; Cu-catalysis; diaminoanthraquinone; Pd-catalysis; Introduction
Bile acids are known to ensure vital processes in vertebrate organisms
arylaminocholanes and cholane-diaminoanthraquinone derivatives by Pd- and Cu-catalyzed amination. Such compounds not only have cation binding properties, but also might be easily introduced in lipid membranes to form ion channels. Appropriate close location of lipophilic steroid fragments in bis(cholanediamino
react with aryl halides to provide a wide range of products in excellent yields. However, yet there was no evidence of the same technique being applied to steroidal amines. Our particular interest was drawn by the synthesis of cholane-diaminoanthraquinone derivatives that can possess good complexation
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Graphical Abstract
Figure 1:
A tripodal molecular pocket (a) [12] or jellyfish resembling receptors (b) [11,16].