Beilstein J. Org. Chem.2017,13, 2561–2568, doi:10.3762/bjoc.13.252
-addition by the activated C=C double bond and subsequent intramolecular recyclization of the intermediate with the amino group involved.
Keywords: cascade reaction; diaminoimidazoles; HPLC–HRESIMS; imidazo[1,5-b]pyridazines; itaconimides; Introduction
Among the numerous bicyclic fused imidazole
14. The capability of diaminoimidazoles in their tautomeric form 4-I to react as 1,3-N,N-dinucleophiles [38] determines the possible formation of adducts 8, whose recyclization could give imidazopyrimidines 15 or imidazodiazepines 16. The amine–imine tautomeric equilibrium is characteristic of
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Graphical Abstract
Scheme 1:
Intramolecular cyclization of 3-(aminomethyl)pyridazines and related compounds (route A). Condition...