Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544

• Yin Chen,
• Jinqiu Ren,
• Ruimin Yang,
• Jie Li,
• Sheng-Xiong Huang and
• Yijun Yan

Beilstein J. Org. Chem. 2022, 18, 1009–1016, doi:10.3762/bjoc.18.101

• daturamycins was identified through gene knockout and biochemical characterization experiments and the biosynthetic pathway of daturamycins was proposed. Keywords: biosynthesis; diarylcyclopentenone; polyporic acid synthetase; p-terphenyl; Streptomyces; Introduction Natural products containing a terphenyl

• condensation between two molecules of α-keto acid. Structurally diverse p-terphenyls are formed from these key intermediates by several tailoring reactions such as cyclization, tautomerization, methylation, and glycosylation. A previous study has shown that the formation of 2,5-diarylcyclopentenone proceeds

• C (3), and three known p-terphenyl derivatives (4–6) (Figure 1) were isolated from the fermentation extract of Streptomyces sp. KIB-H1544. Structurally, daturamycins A and B are uncommon diarylcyclopentenone compounds that consist of a tricyclic 6/5/6 system instead of a C-18 tricyclic skeleton in