Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones

• Aboul-Fetouh E. Mourad,
• Ashraf A. Aly,
• Hassan H. Farag and
• Eman A. Beshr

Beilstein J. Org. Chem. 2007, 3, No. 11, doi:10.1186/1860-5397-3-11

• nearly quantitative yields within few minutes during the reaction of aromatic aldehydes with 5-amino-1(H)-1,2,4-triazole (or 2-aminobenzimidazole) and dimedone in DMF. Conclusion Microwave irradiation can be used as a facile and general method for the construction of a wide variety of

• ) and dimedone (3) in DMF or methanol has been reported previously. [29][30] Fortunately, the microwave irradiation for the reaction containing the starting materials 1a-d, 2 and 3, afforded within a few minutes compounds 4a-d in nearly quantitative yields (Scheme 1). The products 4a,d are the same as

• from the reaction of 7 with the aromatic aldehydes 1a-e and dimedone (3) in DMF. We used the normal method of refluxing (method A) and compared it with the microwave irradiation (method B). The results in Scheme 3 indicated the isolation of products 8a-e by the two methods, however, in different yields