Beilstein J. Org. Chem.2009,5, No. 28, doi:10.3762/bjoc.5.28
partially charged in biological systems. Crystal structures of 2 bound to the active site of nNOS show that the aminopyridine group interacts with a glutamate residue (Glu592, rat nNOS), presumably via hydrogen bonding and electrostaticinteractions [8][12]. The aminopyridine ring nitrogen must be
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Graphical Abstract
Figure 1:
Lead compounds 1 and 2; 2- and 4-aminothiazole analogs 3 and 4a-c.