Acid- mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural products

• Katsunori Tanaka and
• Koichi Fukase

Beilstein J. Org. Chem. 2009, 5, No. 40, doi:10.3762/bjoc.5.40

• prominent biological activity in a “practical” and a “industrial” manner. Keywords: acid-mediated reaction; microreactor; natural products synthesis; oligosaccharide; pristane; Introduction A continuous flow microreactor, an innovative technology, has been used to realize efficient mixing and fast heat

• problems, we used a continuous flow microreactor. An application of the microfluidic system to the glycosylation reaction was first reported by Seeberger and co-workers on α-mannosylation [18]. We also have established an efficient microfluidic glycosylation in combination with the affinity separation

• the synthetic procedure, therefore, we used a continuous flow microreactor. Optimal conditions for reductive opening of 4,6-O-benzylidene acetals by a microfluidic system, similar to the α-sialylation and the β-mannosylation protocols, were examined using the glucose 4,6-O-benzylidene acetal 7 (Table

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditions

• Klaas Mennecke and
• Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 21, doi:10.3762/bjoc.5.21

• -bound ammonium species [23][24][25][26][27][28][29]. These functionalized composite Raschig-rings are incorporated inside the flow microreactor which has a dead volume of about 1–2 mL (Figure 1) [30]. We could show that the palladium clusters are composed of palladium nanoparticles. Particle sizes