Synthesis of novel fluorinated building blocks via halofluorination and related reactions

• Attila Márió Remete,
• Tamás T. Novák,
• Melinda Nonn,
• Matti Haukka,
• Ferenc Fülöp and
• Loránd Kiss

Beilstein J. Org. Chem. 2020, 16, 2562–2575, doi:10.3762/bjoc.16.208

• , Eötvös u. 6, Hungary MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, H-6720 Szeged, Eötvös u. 6, Hungary Department of Chemistry, University of Jyväskylä, FIN-40014, Jyväskylä, Finland 10.3762/bjoc.16.208 Abstract A study exploring halofluorination and fluoroselenation of some

• Deoxo-Fluor®. The fluorine-containing products thus obtained were subjected to elimination reactions, yielding various fluorine-containing small-molecular entities. Keywords: fluorine; fluoroselenation; functionalization; halofluorination; stereocontrol; Introduction The effects of fluorine on

• of halogens [19]. Halofluorinaton-related reactions, such as fluorosulfuration, fluoroselenation, nitrofluorination, and nitriminofluorination, in contrast, are much less studied [20]. Deoxyfluorination, that is fluorine introduction accompanied by oxygen removal (subtypes: OH→F exchange, C=O→CF2