Synthesis and in silico screening of a library of β-carboline-containing compounds

• Kay M. Brummond,
• John R. Goodell,
• Matthew G. LaPorte,
• Lirong Wang and
• Xiang-Qun Xie

Beilstein J. Org. Chem. 2012, 8, 1048–1058, doi:10.3762/bjoc.8.117

• Kay M. Brummond John R. Goodell Matthew G. LaPorte Lirong Wang Xiang-Qun Xie Department of Chemistry, Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA Department of Pharmaceutical Sciences and Computational Chemical Genomics Center

The use of glycoinformatics in glycochemistry

• Thomas Lütteke

Beilstein J. Org. Chem. 2012, 8, 915–929, doi:10.3762/bjoc.8.104

• aid with quality control. Specific problems of glycoinformatics compared to bioinformatics for genomics or proteomics, especially concerning integration and long-term maintenance of the existing glycan databases, are also discussed. Keywords: carbohydrates; databases; glycomics; software

• , such as bioinformatics for genomics or proteomics, for a long time. By now, however, glycoinformatics is coming of age and offers a variety of databases and applications that are of use to glycoscientists. Many new resources are still being developed, and efforts for a better integration of existing

• is obvious that a lot of knowledge on carbohydrates is stored in the databases, but also that this knowledge is widely spread over the resources. In contrast to genomics or proteomics databases, hardly any exchange of data is carried out between glycan databases. However, some attempts have been made

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

• Chao Che,
• Song Li,
• Bo Yang,
• Shengchang Xin,
• Zhixiong Yu,
• Taofeng Shao,
• Chuanye Tao,
• Shuo Lin and
• Zhen Yang

Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94

• Chao Che Song Li Bo Yang Shengchang Xin Zhixiong Yu Taofeng Shao Chuanye Tao Shuo Lin Zhen Yang Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole- based inhibitors of neuronal nitric oxide synthase

• Graham R. Lawton,
• Haitao Ji,
• Pavel Martásek,
• Linda J. Roman and
• Richard B. Silverman

Beilstein J. Org. Chem. 2009, 5, No. 28, doi:10.3762/bjoc.5.28

• of Texas Health Science Center, San Antonio, Texas (USA) Department of Pediatrics and Center for Applied Genomics, 1st School of Medicine, Charles University, Prague, Czech Republic 10.3762/bjoc.5.28 Abstract Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing