Beilstein J. Org. Chem.2012,8, 1569–1575, doi:10.3762/bjoc.8.179
results, however, in the formation of the cyclic isoindolinone or the open 2-carboxyphenylglycine methyl esters, with the reaction outcome being driven by the choice of the solvent.
Keywords: C–H functionalization; carbonylation; glutamic acid; glutamide; palladium; phenylglycine; Introduction
The
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Graphical Abstract
Scheme 1:
Synthesis of methyl (1H)-isoindolin-1-one-3-carboxylates by carbonylation of phenylglycine derivati...