Beilstein J. Org. Chem.2012,8, 2142–2148, doi:10.3762/bjoc.8.241
monitor the natural disaccharide released from varianose by mild acid degradation. The synthesis, performed by the glycosylaldonolactone approach, involved a glucosylgalactofuranose derivative, suitable for the synthesis of higher oligosaccharides with an internal D-Galf.
Keywords: α-D-galactofuranose
; glucosylgalactofuranose; glycosylaldonolactone; Penicillium varians; varianose; Introduction
Carbohydrates are involved in a wide range of biological processes; they play important roles in host–pathogen interactions and in the immune response, where protein–glycan interactions mediate a variety of biological processes
-Galf (8) and α-D-Glcp (1→2)-D-Gal (1)
D-Galactono-1,4-lactone has long been used in our laboratory as a good precursor of the galactofuranosyl units in disaccharides, by using the glycosylaldonolactone approach. This method has the advantage of providing selectively substituted derivatives of the