Beilstein J. Org. Chem.2022,18, 1707–1719, doi:10.3762/bjoc.18.181
Nicolas Fay Remi Blieck Cyrille Kouklovsky Aurelien de la Torre Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, CNRS, 15, rue Georges Clémenceau, 91405 Orsay Cedex, France 10.3762/bjoc.18.181 Abstract Grayananes are a broad family of diterpenoids found in
of each strategy, as well as the challenges remaining to be tackled.
Keywords: enantioselectivity; grayananes; oxidation; 1,2-shift; total synthesis; Introduction
The Ericaceae are a large plant family, with over 4250 known species all around the world [1]. While Ericaceae’s toxicity has been known
gastrointestinal disorders), and for crop protection [2].
Among natural products formed by Ericaceae, grayananes are a wide diterpenoid family whose biological activities are often representative of Ericaceae’s use in traditional medicine [3][4][5]. In particular, many grayananes were found to have analgesic [6
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Graphical Abstract
Figure 1:
General structure of grayanane natural products.