Beilstein J. Org. Chem.2021,17, 156–165, doi:10.3762/bjoc.17.16
, 60, Avenue Rockefeller, Bioparc, Bioserra 1 Building, 69008 Lyon, France 10.3762/bjoc.17.16 Abstract In our hands, efficient access to the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant
-azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one; Introduction
During a recent medicinal chemistry program targeting a kinase to treat skin disorders, we identified the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one motif (1) as an interesting starting point. Recently, both
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Graphical Abstract
Figure 1:
Retrosynthetic disconnection of our privileged kinase scaffold 1.