On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

• Renato L. Carvalho,
• Amanda S. de Miranda,
• Mateus P. Nunes,
• Roberto S. Gomes,
• Guilherme A. M. Jardim and
• Eufrânio N. da Silva Júnior

Beilstein J. Org. Chem. 2021, 17, 1849–1938, doi:10.3762/bjoc.17.126

Activation of pentafluoropropane isomers at a nanoscopic aluminum chlorofluoride: hydrodefluorination versus dehydrofluorination

• Maëva-Charlotte Kervarec,
• Thomas Braun,
• Mike Ahrens and
• Erhard Kemnitz

Beilstein J. Org. Chem. 2020, 16, 2623–2635, doi:10.3762/bjoc.16.213

• such as hydrodefluorinations and dehydrofluorinations were observed, followed by hydroarylation and Friedel–Crafts-type reactions under mild conditions. Keywords: aluminum fluoride; C–F bond activation; dehydrofluorination; hydrodefluorination; hydrofluorocarbons; Introduction Hydrofluorocarbons

• HSiEt3 as a hydrogen source to produce, in the presence of benzene as the solvent, Friedel–Crafts products as main compounds [47]. In contrast, the hydrodefluorination products were generated in the absence of benzene. Thermodynamically, the generation of strong H–F, Al–F, or Si–F bonds can enforce an

• activation of C–F bonds under mild conditions, and hence the addition of the silane HSiEt3 as a hydrogen source [27][48][49]. More recently, ACF was shown to efficiently convert the fluoroalkenes HFO-1234yf (1) and HFO-1234ze (4a) in the presence of the hydrogen source HSiEt3 into the hydrodefluorination or