Beilstein J. Org. Chem.2011,7, 699–716, doi:10.3762/bjoc.7.81
, Potchefstroom 2520, South Africa Macromolecular Chemistry and Organic Catalysis, Institute of Chemistry (B6a), University of Liège, Sart Tilman, Liège 4000, Belgium 10.3762/bjoc.7.81 Abstract By focusing on recent developments on natural and non-natural azasugars (iminocyclitols), this review bolsters the case
for the role of olefin metathesis reactions (RCM, CM) as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable
; iminocyclitols; natural products; olefin metathesis; Ru-alkylidene catalysts; Review
Introduction
Synthetic and natural polyhydroxylated N-heterocyclic compounds (pyrrolidines, piperidines, piperazines, indolizines, etc., and higher homologues), commonly referred to as azasugars, iminosugars or iminocyclitols
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Graphical Abstract
Scheme 1:
Well-defined Mo- and Ru-alkylidene metathesis catalysts.