Beilstein J. Org. Chem.2023,19, 204–211, doi:10.3762/bjoc.19.19
configuration of each enantiomer was determined by single-crystal X-ray analysis. In addition, a one-pot synthesis of (±)-incarviditone has been achieved from rac-rengyolone by using KHMDS as a base. We have also assessed the anticancer activity of all the synthesized compounds in breast cancer cells
nonetheless, they exhibited very limited growth suppression activity.
Keywords: dimerization; incarviditone; incarvilleatone; oxa-Michael; Rauhut–Currier; Introduction
(±)-Incarvilleatone (1) is a dimeric cyclohexylethanoid isolated by Zhang and co-workers [1] in racemic form from the Chinese plant
structure of rac-incarvilleatone (1) was determined by spectroscopic methods and single crystal X-ray analysis. However, they were unable to obtain single crystals of either of the enantiomers (−)-incarvilleatone [(−)-1] and (+)-incarvilleatone [(+)-1]. (±)-Incarviditone (2), a novel benzofuranone dimer was
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Graphical Abstract
Figure 1:
Structures of (±)-incarvilleatone (1), (±)-incarviditone (2), and (±)-rengyolone (3).