Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

• Kayoko Hayashida,
• Taishi Higashi,
• Daichi Kono,
• Keiichi Motoyama,
• Koki Wada and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2014, 10, 2756–2764, doi:10.3762/bjoc.10.292

• such as polyethylene glycol (PEG). On the other hand, PEGylated liposomes have been utilized as a representative anticancer drug carrier. However, little is known about the formation of CD PPRX with PEGylated liposome. In the present study, we first report the formation of CD PPRX with PEGylated

• useful as sustained gene transfer carriers [26][27]. Liposomes (LPs) are microscopic phospholipid vesicles with a bilayered membrane structure and are used as a promising drug carrier [28]. When conventional LPs are administrated intravenously, they are coated with plasma proteins, which results in a

Photo, thermal and chemical degradation of riboflavin

• Muhammad Ali Sheraz,
• Sadia Hafeez Kazi,
• Sofia Ahmed,
• Zubair Anwar and
• Iqbal Ahmad

Beilstein J. Org. Chem. 2014, 10, 1999–2012, doi:10.3762/bjoc.10.208

• reducing the patient compliance [73]. Incorporation into liposomes Entrapment of RF within lipid bilayered vesicles (liposomes) is another approach to improve the photostability of the vitamin and various studies related to such preparations have been conducted [111][137][138][139][140][141][142][143]. The

• composition of liposomes, pH of the preparation and concentration of ingredients may influence the photostability of the liposomal preparation as an increase in the concentration of dimyristoyl-phosphatidylcholine resulted in better photostability of RF. Similarly, an enhanced photostability of RF was

• observed in neutral or negatively charged liposomes while a decrease was noted in positively charged liposomes. The photodegradation of RF followed first-order kinetics both in the presence and absence of liposomes [138]. Highest stability of RF in a liposome was observed when the vitamin was complexed and

Postsynthetic functionalization of glycodendrons at the focal point

• Thisbe K. Lindhorst and
• Katharina Elsner

Beilstein J. Org. Chem. 2014, 10, 1482–1487, doi:10.3762/bjoc.10.152

• films, liposomes, or membranes. Focal functionalization of dendrons can be performed prior to modification of the multivalent dendron periphery, or as postsynthetic modification. However, postsynthetic functionalization of the focal point of a rather bulky molecule is not necessarily facile owing to

Automated solid-phase peptide synthesis to obtain therapeutic peptides

• Veronika Mäde,
• Sylvia Els-Heindl and
• Annette G. Beck-Sickinger

Beilstein J. Org. Chem. 2014, 10, 1197–1212, doi:10.3762/bjoc.10.118

• the integration of peptides into particles, gels or liposomes [14][82][83]. Recently, the great methodical repertoire for extending the half-lifes of biological active peptides by covalent chemical approaches has been reviewed [8]. These methods include peptide sequence modifications by non

Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology

• Jan Anderl,
• Hartmut Echner and
• Heinz Faulstich

Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233

• ”, and Emi et al. [24] used polyarginine as a carrier for gene transfer. Protein transduction domains such as Tat-peptide, usually consisting of 10–30 amino acids, have been used to transport enzymes, drugs, liposomes and supermagnetic particles into cells [25][26][27][28][29]. In the meantime it has

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• chains burying into the membrane. This effect was most pronounced in the presence of anionic liposomes, but all of the mixtures resulted in strong decreases in the calculated Ksv values (Figure 3). The other two peptides, gp41w-KA and gp41w-FKA, demonstrate a preference for anionic lipids and detergents

• , as the Ksv values determined in the presence of SDS micelles and LUVs containing ePG lipids are much lower than those determined in the presence of DPC or zwitterionic liposomes (Figure 3). When the peptides were added to ePC:ePE LUVs, there was only a small decrease in the calculated Ksv. This

• suggests that these two peptides interact only weakly with the neutral liposomes. The decrease in Ksv observed in the presence of DPC micelles is likely due to the high concentration of detergent used in these samples. These conditions shift the equilibrium of the free-floating peptide in solution to the

Binding of group 15 and group 16 oxides by a concave host containing an isophthalamide unit

• Jens Eckelmann,
• Vittorio Saggiomo,
• Svenja Fischmann and
• Ulrich Lüning

Beilstein J. Org. Chem. 2012, 8, 11–17, doi:10.3762/bjoc.8.2

• applied to chloride-loaded liposomes [22], it showed twice as much transmembrane chloride transport with respect to acyclic compound 2 (see Supporting Information File 1). Even if the chloride binding is lower for concave host 1, the transport through a bilayer membrane is faster. Additional transport

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• concentration of free surfactant in the aqueous phase. The hydrophilic part is most often constructed from PEG chains. In addition to the steric stabilization, this PEG coating reduces the detection of particles or liposomes by the immune system and consequently, the reticular endothelial uptake of