Beilstein J. Org. Chem.2020,16, 3078–3085, doi:10.3762/bjoc.16.257
Chemical Technology, Daejeon 34114, Republic of Korea Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea 10.3762/bjoc.16.257 Abstract A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis
effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.
Keywords: antineuroinflammation; Chaenomeles sinensis; cytotoxicity; megastigmane; neurotrophic effect; Introduction
Chaenomeles sinensis (Thouin) Koehne (Rosaceae
a new megastigmane-type norsesquiterpenoid glycoside 1 along with 11 known compounds (2–12, Figure 1). The structure of the new compound 1 was established on the basis of spectroscopic and spectrometric data analysis, and chiral derivatization coupled with NMR or LC–MS experiments. All isolated