Beilstein J. Org. Chem.2017,13, 285–300, doi:10.3762/bjoc.13.31
optimization is discussed.
Keywords: expert systems; flow chemistry; microcoil; NMR probes; Introduction
New enabling technologies have facilitated the transition from traditional chemistry to a more automated approach that will be the chemistry of the 21st century [1][2]. The objective is that the reaction
breakage of glass sample tubes.
Microcoil probes
An interesting way to increase the sensitivity of NMR is the use of microcoil probes [15][16]. Based on the reciprocity principle [15], it has been shown that for a constant length-to-diameter ratio, the NMR detector (i.e., coil) sensitivity is inversely
requirements for the spatial B0 field homogeneity, the construction of the probe for the highest sensitivity and resolution is a challenging task. The latter falls outside the scope of this review and instead, we will describe the types and features of microcoil probes in this section and its integration with
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Graphical Abstract
Figure 1:
Graphical representation of (a) conventional flow cell with a saddle-shaped RF coil and (b) flow ca...