Beilstein J. Org. Chem.2019,15, 623–632, doi:10.3762/bjoc.15.58
study the mechanisms of immune modulation. In this study, a new bioerodible polyanhydride microparticle was designed and conjugated with a glycodendrimer molecular probe. This molecular probe incorporates a pathogen-like multivalent display of α-1,2-trimannose, for which a more efficient synthesis was
designed, with a tethered fluorophore. Further attachment of the glycodendrimer to a biocompatible, surface eroding microparticle allows for targeted uptake and internalization of the pathogen-associated oligosaccharide by phagocytic immune cells. The α-1,2-trimannose-linked bioerodible microparticles were
recognition by pathogen-recognition receptors during L. major-induced leishmaniasis.
Keywords: adjuvant; carbohydrates; L. major; microparticle; PAMP; Introduction
Recognition of parasite cell surface molecules by host immune cells initiates the first step in the immune response [1][2]. The host’s immune
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Graphical Abstract
Figure 1: Leishmania lipophosphoglycan (LPG), with Gal-β-(1→4)-[Man-α-(1→2)-Man-α-(1→2)-Man] variant capping ...