Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids

• Simon Drescher,
• Vasil M. Garamus,
• Christopher J. Garvey,
• Annette Meister and
• Alfred Blume

Beilstein J. Org. Chem. 2017, 13, 995–1007, doi:10.3762/bjoc.13.99

• was studied as a function of temperature using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and small angle neutron scattering (SANS). We show that our new bolalipid self-assembles into nanofibres, which transform into

• flexible nanofibres at 27 °C and further to small elongated micelles at 45 °C. Furthermore, the miscibility of the bolalipid with bilayer-forming phosphatidylcholines (DMPC, DPPC, and DSPC) was investigated by means of DSC, TEM, FTIR, and small angle X-ray scattering (SAXS). We could show that the PC

• behaviour; nanofibres; self-assembly; Introduction Bolalipids are amphiphilic molecules consisting of two hydrophilic headgroups attached to both ends of a long hydrocarbon spacer [1]. The hydrophobic spacer is composed of either a single alkyl chain or two chains connected via a glycerol moiety. These

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

• Qiang Wei,
• Theresa L. M. Pohl,
• Anja Seckinger,
• Joachim P. Spatz and
• Elisabetta A. Cavalcanti-Adam

Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87

• understanding the mechanotransduction for regulating stem cell fate. As a reverse process of cell differentiation, integrin adhesion also influences the reprogramming of differentiated cells to pluripotency. In a recent study, fibroblast adhesion is regulated by parallel microgrooves and aligned nanofibres

Molecular assembly of amino acid interlinked, topologically symmetric, π-complementary donor–acceptor–donor triads

• M. B. Avinash,
• K. V. Sandeepa and
• T. Govindaraju

Beilstein J. Org. Chem. 2013, 9, 1565–1571, doi:10.3762/bjoc.9.178

• naphthalenediimide (NDI) based novel donor–acceptor–donor (D-A-D) triads are designed to exploit their topological symmetry and complementary π-character for facile charge-transfer complexation. Consequently, free-floating high-aspect-ratio supercoiled nanofibres and hierarchical helical bundles of triads are

• (FESEM). FESEM images of 1 in 40% aqueous NMP showed the presence of supercoiled nanofibres of ~10 nm diameter and a helical pitch of ~30 nm (Figure 4a). At 80% aqueous NMP, a dense network of nanofibres of 1 was observed (see Supporting Information File 1). Interestingly, at 80% aqueous NMP, 2 was found

• symmetric and π-complementary pyrene and NDI. Consequently, free-floating high-aspect-ratio supercoiled nanofibres and hierarchical helical bundles of triads are realized by modulating the chemical functionality of interlinking amino acids. Such molecular-recognition processes embodied in pertinent designer

The synthesis of well-defined poly(vinylbenzyl chloride)-grafted nanoparticles via RAFT polymerization

• John Moraes,
• Kohji Ohno,
• Guillaume Gody,
• Thomas Maschmeyer and
• Sébastien Perrier

Beilstein J. Org. Chem. 2013, 9, 1226–1234, doi:10.3762/bjoc.9.139

• polymerization (ATRP) [30][31]. It has, therefore, been used in a variety of systems as a precursor to glycopolymer stars [29], photo- and pH-responsive nanoparticles [30], nanofibres [28], comb, graft and star polymers [27], and triblock copolymers [26]. While there have been reports of the (co)polymerization

Organic gelators and hydrogelators

• Jean-Pierre Desvergne

Beilstein J. Org. Chem. 2010, 6, 846–847, doi:10.3762/bjoc.6.99

• transition by heating and cooling) and, depending on the molecular structure of the gelling agent and the fluid which is rigidified, it is possible to form nanoscale superstructures such as nanofibres, nanoribbons, nanosheets, nanoparticles, helical windings, etc., which are of interest for materials and

Symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems

• Sławomir Boncel,
• Maciej Mączka,
• Krzysztof K. K. Koziol,
• Radosław Motyka and
• Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2010, 6, No. 34, doi:10.3762/bjoc.6.34

• nanofibres. Keywords: amides; antiprotozoal agents; coupling; nucleosides; self-assembly; Introduction There are numerous reports on the synthesis and application of symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems (Figure 1) [1][2][3][4][5][6]. These molecules are constructed usually

• 1,10-diaminodecane may form nanofibres of 80–300 nm diameter for thymine and 15–100 nm for 5-nitrouracil derivatives, respectively. The electron diffraction patterns in the case of 11 indicate single crystal fibre diffraction (Figure 4A). A simplified model for the formation of multilayered nanofibres

• is shown in Figure 5. A proposal of simplified models of micro- and nanofibres is based on the π-stacking and hydrogen bonding interactions between thymine units. Amide bonds, on the other hand, may be crucial in the inter-layer hydrogen bonding. A linear system of hydrogen bonding appears as a