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Search for "nanosponges" in Full Text gives 14 result(s) in Beilstein Journal of Organic Chemistry.

Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers

  • Alberto Rubin Pedrazzo,
  • Fabrizio Caldera,
  • Marco Zanetti,
  • Silvia Lucia Appleton,
  • Nilesh Kumar Dhakar and
  • Francesco Trotta

Beilstein J. Org. Chem. 2020, 16, 1554–1563, doi:10.3762/bjoc.16.127

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  • Alberto Rubin Pedrazzo Fabrizio Caldera Marco Zanetti Silvia Lucia Appleton Nilesh Kumar Dhakar Francesco Trotta Dipartimento di Chimica, Università degli Studi di Torino, Via Giuria 7, Torino 10125, Italy 10.3762/bjoc.16.127 Abstract Cyclodextrin nanosponges (CD-NS) are nanostructured
  • , and rhodamine B) and the still reactive imidazoyl carbonyl group of the NS. Keywords: β-cyclodextrin; ball-milling; crosslinking; green chemistry; mechanochemistry; nanosponges; Introduction The research in the fields of nanomedicine and nanotechnology has nowadays become predominant
  • . Polysaccharides and, among them, starch derivatives such as cyclodextrins (CD), have recently emerged as they are safe, of low cost and biodegradable. Cyclodextrin nanosponges (CD-NS) are crosslinked cyclodextrin polymers characterized by a nanosized three-dimensional network. The reactive hydroxy groups of CDs
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Published 29 Jun 2020

Reaction of oxiranes with cyclodextrins under high-energy ball-milling conditions

  • László Jicsinszky,
  • Federica Calsolaro,
  • Katia Martina,
  • Fabio Bucciol,
  • Maela Manzoli and
  • Giancarlo Cravotto

Beilstein J. Org. Chem. 2019, 15, 1448–1459, doi:10.3762/bjoc.15.145

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  • most commonly used CDPs [1], more so than the so-called “nanosponges” [2], as well as being more chemically stable in both aqueous and alcoholic media. Their industrial-scale preparation has been designed and uses sodium hydroxide as the base in a very concentrated aqueous CD solution [3]. The low
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Published 01 Jul 2019

Polyaminoazide mixtures for the synthesis of pH-responsive calixarene nanosponges

  • Antonella Di Vincenzo,
  • Antonio Palumbo Piccionello,
  • Alberto Spinella,
  • Delia Chillura Martino,
  • Marco Russo and
  • Paolo Lo Meo

Beilstein J. Org. Chem. 2019, 15, 633–641, doi:10.3762/bjoc.15.59

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  • . The desired responsivity to pH variations of the nanosponges obtained was verified by means of absorption tests on a set of organic pollutant model molecules. Keywords: calixarenes; nanosponges; pH-responsive materials; pollutants; polyaminoazides; Introduction The ability to provide a response to
  • nanosponge materials with tunable properties. Nanosponges (NSs) [7][8][9][10][11][12][13][14] are hyper-cross-linked polymers or copolymers obtained by reacting supramolecular host species as the monomer units with suitable reticulating agents. Of course, the structural, physical and chemical features of the
  • . More recently, we also reported the synthesis of entirely synthetic calixarene nanosponges (CaNSs) [22], which can be prepared by means of the same CuAAC approach, by reacting a tetrakis(propargyloxy)calix[4]arene with a diazidoalkane. Of course, the reaction results in the formation of bis(1,2,3
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Published 12 Mar 2019

Hyper-reticulated calixarene polymers: a new example of entirely synthetic nanosponge materials

  • Alberto Spinella,
  • Marco Russo,
  • Antonella Di Vincenzo,
  • Delia Chillura Martino and
  • Paolo Lo Meo

Beilstein J. Org. Chem. 2018, 14, 1498–1507, doi:10.3762/bjoc.14.127

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  • , V.le delle Scienze ed. 17, 90128 Palermo, Italy 10.3762/bjoc.14.127 Abstract New calixarene-based nanosponges (CaNSs), i.e., hyper-reticulated polymers constituted by calixarene monomer units joined by means of bis(1,2,3-trialzolyl)alkyl linkers, were synthesized, characterized and subjected to
  • efficiency indeed depends on the effective occurrence of both electrostatic and hydrophobic interactions between the guest and the polymer lattice. Thus, our CaNS nanosponges can be considered as a new class of purely synthetic smart absorbent materials. Keywords: calixarenes; nanosponges; smart materials
  • ; solid-state NMR; Introduction Nanosponges (NSs) [1][2][3] constitute an emerging area of both materials chemistry and supramolecular chemistry due to their peculiar properties, which have been object of an increasing interest during the last years. These materials are constituted by hyper-reticulated
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Published 20 Jun 2018

Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays

  • Marco Russo,
  • Daniele La Corte,
  • Annalisa Pisciotta,
  • Serena Riela,
  • Rosa Alduina and
  • Paolo Lo Meo

Beilstein J. Org. Chem. 2017, 13, 2751–2763, doi:10.3762/bjoc.13.271

Graphical Abstract
  • ][41]. Moreover, the same products have been used for the synthesis of pH-responsive nanosponges [42]. In view of possible further applications, the present work is aimed at verifying the abilities of AmCD materials synthesized by us to act as bimodal supramolecular ligands. To the best of our
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Published 18 Dec 2017

Dynamics and interactions of ibuprofen in cyclodextrin nanosponges by solid-state NMR spectroscopy

  • Monica Ferro,
  • Franca Castiglione,
  • Nadia Pastori,
  • Carlo Punta,
  • Lucio Melone,
  • Walter Panzeri,
  • Barbara Rossi,
  • Francesco Trotta and
  • Andrea Mele

Beilstein J. Org. Chem. 2017, 13, 182–194, doi:10.3762/bjoc.13.21

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  • of Chemistry, University of Torino, Via Pietro Giuria 7, 10125 Torino, Italy 10.3762/bjoc.13.21 Abstract Two different formulations of cyclodextrin nanosponges (CDNS), obtained by polycondensation of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn), were treated with aqueous
  • reported matched the information from powder X-ray diffraction profiles. Keywords: cross-polarization; cyclodextrin; ibuprofen; nanosponges; solid-state NMR; Introduction In the last ten years cyclodextrin nanosponges (CDNS) polymer materials received great attention as promising new materials in several
  • ) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) in two different preparations: CDNS(1:4) and CDNS(1:8), where the 1:n notation indicates the CD to EDTAn molar ratio used for the synthesis. The
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Published 27 Jan 2017

Stabilization of nanosized titanium dioxide by cyclodextrin polymers and its photocatalytic effect on the degradation of wastewater pollutants

  • Tamás Zoltán Agócs,
  • István Puskás,
  • Erzsébet Varga,
  • Mónika Molnár and
  • Éva Fenyvesi

Beilstein J. Org. Chem. 2016, 12, 2873–2882, doi:10.3762/bjoc.12.286

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  • technologies (e.g., in situ/ex situ microbial degradation and chemical oxidation of contaminants in soil) [9][10]. Immobilizing CDs either by crosslinking or by coupling to the surface of natural or synthetic polymers CD-based sorbents are obtained in the form of beads, nanosponges, microfibers, etc., which
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Published 28 Dec 2016

Enabling technologies and green processes in cyclodextrin chemistry

  • Giancarlo Cravotto,
  • Marina Caporaso,
  • Laszlo Jicsinszky and
  • Katia Martina

Beilstein J. Org. Chem. 2016, 12, 278–294, doi:10.3762/bjoc.12.30

Graphical Abstract
  • activity was preserved in the final solid cross-linked β-CD enzyme [36]. Nanosponges are nanostructured materials made of hyper-cross-linked CDs [37]. The capacity of these materials to encapsulate a great variety of substances could be used to design innovative drug carriers, to protect degradable
  • substances and to improve the aqueous solubility of poorly water-soluble molecules. α-, β- and γ-CDs were reacted solventless with diphenyl carbonate or carbonyldiimidazole under US (up to 90 °C). These nanosponges may resolve some active ingredients drawbacks, such as instability, degradation, poor
  • methanediphenyl diisocyanate [76]. The authors demonstrated that compared with conventional heating, the reaction was faster (3–10 min) and with higher yields. Analogously, β-CD was grafted onto PEGylated Merrifield resin by reaction with HDI under MW irradiation [77]. CD nanosponges from anhydrous β-CD and
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Published 15 Feb 2016

Polydisperse methyl β-cyclodextrin–epichlorohydrin polymers: variable contact time 13C CP-MAS solid-state NMR characterization

  • Isabelle Mallard,
  • Davy Baudelet,
  • Franca Castiglione,
  • Monica Ferro,
  • Walter Panzeri,
  • Enzio Ragg and
  • Andrea Mele

Beilstein J. Org. Chem. 2015, 11, 2785–2794, doi:10.3762/bjoc.11.299

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  • , efficient and environmentally sustainable route to highly cross-linked, nanoporous polymers commonly referred to as cyclodextrin nanosponges. One of the most frequently used crosslinker for insoluble polymers is epichlorohydrin (EP). In this case, the reaction of β-CD with EP requires very strong alkaline
  • cyclodextrin nanosponges [41]. A striking feature from the data in Table 2 is that the values of T1ρ for all the H atoms of the three polymers are basically the same, with no particular variation related to structure or the synthetic route. In particular, it seems that the imprinting process has no effect on
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Published 30 Dec 2015

Aggregation behaviour of amphiphilic cyclodextrins: the nucleation stage by atomistic molecular dynamics simulations

  • Giuseppina Raffaini,
  • Antonino Mazzaglia and
  • Fabio Ganazzoli

Beilstein J. Org. Chem. 2015, 11, 2459–2473, doi:10.3762/bjoc.11.267

Graphical Abstract
  • attracting an increasing attention [1][2][3][4][5][6][7][8], including also the new polymeric CD nanogels [9] and nanosponges [10][11][12][13]. Over the past twenty years, amphiphilic cyclodextrins (aCD) formed with α-, β-, or γ-CD have given rise to a wide interest in the scientific community because of
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Published 07 Dec 2015

Anomalous diffusion of Ibuprofen in cyclodextrin nanosponge hydrogels: an HRMAS NMR study

  • Monica Ferro,
  • Franca Castiglione,
  • Carlo Punta,
  • Lucio Melone,
  • Walter Panzeri,
  • Barbara Rossi,
  • Francesco Trotta and
  • Andrea Mele

Beilstein J. Org. Chem. 2014, 10, 2715–2723, doi:10.3762/bjoc.10.286

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  • .10.286 Abstract Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) in two different preparations: CDNSEDTA 1:4 and 1:8, where the 1:n notation indicates the CD to EDTAn molar
  • -linked polymers; cyclodextrin nanosponges; diffusion; HRMAS NMR spectroscopy; TEM; Introduction Cyclodextrin nanosponges (CDNS) are a novel, promising class of nanoporous, three-dimensional polymers with interesting properties of sorption of both organic and inorganic species [1][2][3]. Indeed, several
  • potential use in therapy. In this work we present a study based on HRMAS NMR spectroscopy on the transport properties of Ibuprofen sodium salt (IP) confined in CDNSEDTA nanosponge hydrogels. Here, two different formulation of the nanosponges are investigated, characterized by a different CD/cross linker
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Published 19 Nov 2014

Synthesis and characterization of a hyper-branched water-soluble β-cyclodextrin polymer

  • Francesco Trotta,
  • Fabrizio Caldera,
  • Roberta Cavalli,
  • Andrea Mele,
  • Carlo Punta,
  • Lucio Melone,
  • Franca Castiglione,
  • Barbara Rossi,
  • Monica Ferro,
  • Vincenza Crupi,
  • Domenico Majolino,
  • Valentina Venuti and
  • Dominique Scalarone

Beilstein J. Org. Chem. 2014, 10, 2586–2593, doi:10.3762/bjoc.10.271

Graphical Abstract
  • organometallic reactions [1] to emulsion polymerization [2][3][4]. By reacting CDs with suitable crosslinking agents, nanostructured hyper-cross-linked materials, known as nanosponges, can be obtained [5][6][7]. Currently there is a growing interest in the synthesis of soluble β-CD-based polymers, which is a
  • , gelation occurs. The same happens by using a lower amount of catalyst, if any. Nevertheless, many papers have been published regarding the so called CD nanosponges that are highly cross-linked CD polymers [15][16]. Recently a detailed investigation of these novel nanomaterials allowed to clarify some
  • structural aspects and functional properties, and in particular pyromellitic nanosponges were found to present a critical cross-linking value [17]. In other words, the maximum number of cross-linkers per monomer was proved to be around 6 (i.e., 6 mol of pyromellitic dianhydride for each mol of β-CD). If the
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Published 06 Nov 2014

Cyclodextrin-based nanosponges as drug carriers

  • Francesco Trotta,
  • Marco Zanetti and
  • Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

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  • nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or
  • biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to
  • achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine. Keywords: controlled release
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Published 29 Nov 2012

Cyclodextrin nanosponge-sensitized enantiodifferentiating photoisomerization of cyclooctene and 1,3-cyclooctadiene

  • Wenting Liang,
  • Cheng Yang,
  • Masaki Nishijima,
  • Gaku Fukuhara,
  • Tadashi Mori,
  • Andrea Mele,
  • Franca Castiglione,
  • Fabrizio Caldera,
  • Francesco Trotta and
  • Yoshihisa Inoue

Beilstein J. Org. Chem. 2012, 8, 1305–1311, doi:10.3762/bjoc.8.149

Graphical Abstract
  • )-cyclooctene and (Z,Z)-1,3-cyclooctadiene were performed by using the pyromellitate-linked cyclodextrin network polymer, termed “cyclodextrin nanosponge (CDNS)”, as a supramolecular sensitizing host. The photochirogenic behavior of the nanosponges incorporating β- or γ-cyclodextrin was significantly different
  • photochirogenesis to use pyromellitate-linked polymeric β- and γ-CDs, termed “cyclodextrin nanosponges” (CDNSs) [25][26][27][28][29][30][31][32][33], as sensitizing hosts for the enantiodifferentiating photoisomerization of (Z)-cyclooctene (1Z) [34][35][36][37] and (Z,Z)-1,3-cyclooctadiene (2ZZ) [38][39][40
  • extraction with acetone, as reported previously [41]. We termed these cross-linked CD network polymers as “nanosponges”, because these CD-based polymers show a nanoporous structure and a property of swelling upon absorption of water. The ability to entrap organic molecules can be ascribed to both the pores
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Published 16 Aug 2012
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