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Search for "netropsin" in Full Text gives 4 result(s) in Beilstein Journal of Organic Chemistry.

Photocontrolled DNA minor groove interactions of imidazole/pyrrole polyamides

  • Sabrina Müller,
  • Jannik Paulus,
  • Jochen Mattay,
  • Heiko Ihmels,
  • Veronica I. Dodero and
  • Norbert Sewald

Beilstein J. Org. Chem. 2020, 16, 60–70, doi:10.3762/bjoc.16.8

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  • . A major breakthrough concerning selective small DNA-targeting molecules was the use of pyrrole/imidazole hairpin polyamides. They are conceptually derived from the natural products netropsin and distamycin A, which selectively bind to particular sequences of the DNA duplex [2][3][4]. Covalent
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Published 09 Jan 2020

An overview of recent advances in duplex DNA recognition by small molecules

  • Sayantan Bhaduri,
  • Nihar Ranjan and
  • Dev P. Arya

Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93

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  • particular, we cover the advances made in DNA minor groove recognition using new analogues and derivatives of classical minor groove binders such as distamycin, netropsin, polyamides, bisbenzimidazoles and organic cations. We have also included new intercalating agents as well as major groove binding ligands
  • group of the guanine base [19]. 2.1. Polypyrroles and polyamides The first two MGBs discovered were distamycin A and netropsin (Figure 3). These naturally occurring molecules are characterized by repeating N-methylpyrrole units with one or more positively charged nitrogen atoms at the end. Their concave
  • as inhibitors of Werner and Bloom syndrome helicases and dual topoisomerase I/II inhibitors [37][38]. In order to improve DNA binding affinity and sequence specificity with reduced side effects, a series of synthetic hybrid molecules derived from distamycin and netropsin was synthesized and their
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Published 16 May 2018

Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

  • Mattias Bood,
  • Sangamesh Sarangamath,
  • Moa S. Wranne,
  • Morten Grøtli and
  • L. Marcus Wilhelmsson

Beilstein J. Org. Chem. 2018, 14, 114–129, doi:10.3762/bjoc.14.7

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  • distance window of opportunity than external fluorophores, and, thus, have the potential to facilitate better structure resolution. Netropsin DNA binding and the B-to-Z-DNA transition are examples of structure investigations that recently have been performed using base–base FRET and that are described here
  • . Keywords: B-to-Z-DNA transition; fluorescent base analogues; FRET; netropsin; nucleic acid structure and dynamics; quadracyclic adenines; tricyclic cytosines; Z-DNA; Review Introduction The importance of nucleic acid structure and dynamics in the understanding of vital processes in living organisms has
  • established minor groove binder netropsin [25]. Netropsin is an archetypal minor groove ligand that binds short (4–5 bp) AT-rich sequences [74][75][76]. In our investigation we first measured the FRET efficiencies, using both steady-state and time-resolved emission, between qAN1 and qAnitro separated by 2–13
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Published 10 Jan 2018

Polarization spectroscopy methods in the determination of interactions of small molecules with nucleic acids – tutorial

  • Tamara Šmidlehner,
  • Ivo Piantanida and
  • Gennaro Pescitelli

Beilstein J. Org. Chem. 2018, 14, 84–105, doi:10.3762/bjoc.14.5

Graphical Abstract
  • ligand aggregates binding to polynucleotides (Figure 2). Many naturally occurring small molecules owe different biological activities due to aggregation, for instance, the close analogs netropsin (the single molecule in the DNA minor groove) and distamycin (the dimer in DNA minor groove) [13]. In
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Published 08 Jan 2018
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