Host–guest interactions in nor-seco-cucurbit[10]uril: novel guest-dependent molecular recognition and stereoisomerism

• Xiaodong Zhang,
• Wei Wu,
• Zhu Tao and
• Xin-Long Ni

Beilstein J. Org. Chem. 2019, 15, 1705–1711, doi:10.3762/bjoc.15.166

• photophysical signals to identify the possible diastereomers of guests within nor-seco-cucurbit[10]uril (NS-CB[10]) cavities. Further experiments revealed that balancing the hydrophilic and hydrophobic effects of the guest in aqueous solution can improve the molecular recognition and binding ability of NS-CB[10

• ]. Keywords: fluorescent; host–guest interaction; macrocycles; molecular recognition; nor-seco-cucurbit[10]uril; pyrene; Introduction Host–guest interactions that trigger molecular recognition are a current topic of interest. For example, understanding the protein–ligand molecular recognition is of paramount

• [18][19][20][21][22]. However, forming ternary complexes with Q[8] is challenging because the number of aromatic-derived water-soluble recognition motifs remains limited. In 2006, Isaacs and co-workers reported the synthesis and isolation of nor-seco-cucurbit[10]uril (NS-CB[10], host-1, Scheme 1) [23