Contemporary organosilicon chemistry

• Steve Marsden

Beilstein J. Org. Chem. 2007, 3, No. 4, doi:10.1186/1860-5397-3-4

• . Notwithstanding the earlier, pioneering work of chemists such as Eaborn, 1968 was notable for many innovations we now take for granted, including the development of silyl enol ether chemistry by Stork and Hudrlik, and the eponymous olefination reaction by Peterson. These landmark papers triggered a massive growth

An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

• Biswajit K. Singh,
• Surendra S. Bisht and
• Rama P. Tripathi

Beilstein J. Org. Chem. 2006, 2, No. 24, doi:10.1186/1860-5397-2-24

• aldehydes. Wittig olefination followed by reaction of the resulting tetranolactonyl dienyl esters with different amines resulted in the respective 5-hydroxy lactams. Subsequent dehydration of the hydroxy lactams with p-toluene sulphonic acid afforded the dienyl tetramic acid derivatives. All reactions were

• compounds were determined on the basis of their spectroscopic data (Supporting Information File 1). Wittig olefination of aldehydes 7 and 8 with carbethoxymethylene triphenylphosphorane in THF at ambient temperature led to the formation of the respective exo-dienyl esters of the tetronolactones as a mixture

• studies. In such an earlier study, [37] with BuLi at -78°C used as the base for the Wittig olefination, lower yields and poor stereoselection was observed as compared to our uncatalysed ambient temperature reaction where ZZ isomers were predominantly formed. The Z configuration of the allylic alcohol was

Synthesis of highly substituted allenylsilanes by alkylidenation of silylketenes

• Stephen P. Marsden and
• Pascal C. Ducept

Beilstein J. Org. Chem. 2005, 1, No. 5, doi:10.1186/1860-5397-1-5

• allenylsilane product. We have not as yet examined the use of the more reactive Tebbe reagent which may function effectively at lower temperatures and hence offer a solution to this current limitation. Additionally, it will be of future interest to investigate the chromium-based Takai procedures for olefination