Heteroleptic metallosupramolecular aggregates/complexation for supramolecular catalysis

• Prodip Howlader and
• Michael Schmittel

Beilstein J. Org. Chem. 2022, 18, 597–630, doi:10.3762/bjoc.18.62

• further options. In particular, the protocol of acid addition and removal (upon base addition) may be elegantly replaced by using a suitable fuel acid thus opening the field of supramolecular catalysis for out-of-equilibrium processing. Toggling between intra- and intermolecular complexation in

Trichloroacetic acid fueled practical amine purifications

• Aleena Thomas,
• Baptiste Gasch,
• Enzo Olivieri and
• Adrien Quintard

Beilstein J. Org. Chem. 2022, 18, 225–231, doi:10.3762/bjoc.18.26

• . Inspired by recent work on out of equilibrium molecular machinery, using trichloroacetic acid (TCA), we disclose a purification technique considerably decreasing the number of operations and the waste generation required for such purifications. At first, TCA triggers the precipitation of the amines through

• success. Keywords: amines; decarboxylation; eco-compatible; out of equilibrium; purification; Introduction Isolation of pure amines from reaction mixtures or natural extracts is crucial in modern organic chemistry. However, the most widely applied methods for these purifications have remained unchanged

• operations and the associated generation of waste, discovery of alternative purification techniques is mandatory. Avoiding waste accumulation, dissipative acids have recently found interesting applications in the field of out of equilibrium molecular switches and motors [5]. They enable the temporary

Grip on complexity in chemical reaction networks

• Albert S. Y. Wong and
• Wilhelm T. S. Huck

Beilstein J. Org. Chem. 2017, 13, 1486–1497, doi:10.3762/bjoc.13.147

• chemical entities on the properties of the network as a whole. Ultimately, this approach should allow us to not only understand such complex networks but also to guide and control their behavior. Keywords: chemical reaction network; complexity; dissipative systems; network motifs; out-of-equilibrium

• the design principles of biological systems into a practical “programming language” and learn how to create functionality using chemical reactions. Early work has resulted in numerous exciting examples, ranging from functional out-of-equilibrium systems that can perform logic operations, to

• lay out a general strategy for the design and implementation of CRNs that operate under out-of-equilibrium conditions and show complex behavior. We believe that new approaches are needed to build molecular networks, firmly rooted in (synthetic) chemistry but incorporating mathematical modelling and

Towards open-ended evolution in self-replicating molecular systems

• Herman Duim and
• Sijbren Otto

Beilstein J. Org. Chem. 2017, 13, 1189–1203, doi:10.3762/bjoc.13.118

• blocks. Dynamically evolving out-of-equilibrium environments like these could enable interesting behavior of replicators that is not achievable in homogenous reaction mixtures. It will be very exciting to observe the evolutionary behavior of mixtures of replicators in such spatially resolved environments

How and why kinetics, thermodynamics, and chemistry induce the logic of biological evolution

• Addy Pross and
• Robert Pascal

Beilstein J. Org. Chem. 2017, 13, 665–674, doi:10.3762/bjoc.13.66

• elaborate processes, in particular that of increasing complexity, are clearly involved. As an example of a higher degree of complexity, out-of-equilibrium self-assembly can be observed when reactants that have no affinity for self-assembly in themselves, can be converted upon activation into transient