Beilstein J. Org. Chem.2023,19, 687–699, doi:10.3762/bjoc.19.50
/bjoc.19.50 Abstract Phostams, phostones, and phostines are a series of 1,2-azaphosphaheterocycle and 1,2-oxaphosphaheterocycle 2-oxide derivatives. They are phosphorus analogues of lactams and lactones and important biologically active compounds. The strategies for the synthesis of medium and large
of two ring bonds. This review includes the recent syntheses of seven to fourteen-membered phostam, phostone, and phostine derivatives.
Keywords: azaphosphaheterocycle; oxaphosphaheterocycle; phostam; phostine; phostone; Introduction
Phostams, phostones, and phostines are a class of important
synthesis of 1,2-oxaphosphaheterocycle 2-oxides. tert-Butyl 2-(bis(allyloxy)phosphoryl)pent-4-enoate (11) generated tert-butyl 2-(allyloxy)-3,4,7-trihydro-1,2-oxaphosphepine-3-carboxylate 2-oxide (12) in excellent 94% yield in the presence of the Grubbs catalyst in DCM. After further allylation with allyl
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Graphical Abstract
Figure 1:
Biologically active agents and chiral ligands containing medium and large phostams, phostones, and ...