Beilstein J. Org. Chem.2018,14, 3112–3121, doi:10.3762/bjoc.14.291
carbonyl group at 4 position. Thus, it is generally difficult to synthesize the pentamethyl ether efficiently by conventional methylation. Here, we describe a simple and effective per-O-methylation of quercetin with dimethyl sulfate in potassium (or sodium) hydroxide/dimethyl sulfoxide at room temperature
results.
Keywords: computational calculation; per-O-methylation; quercetin; quercetin pentamethyl ether; reactivity; Introduction
Flavonoids are distributed widely in plants, and exhibit various biological activities [1]. Polymethoxyflavones (PMFs) in particular have attracted much attention due to
][35][36], though 1 was smoothly obtained in other cases [37][38][39][40]. Therefore, we set out to re-examine the per-O-methylation of 2 in detail. In this paper, we describe a simple, practical and effective preparation of 1 from quercetin (2). A computational study of the methylation reactions of 2
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Graphical Abstract
Figure 1:
Structures of quercetin pentamethyl ether (QPE, 1) and quercetin (2).