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Search for "per-O-methylation" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

A simple and effective preparation of quercetin pentamethyl ether from quercetin

  • Jin Tatsuzaki,
  • Tomohiko Ohwada,
  • Yuko Otani,
  • Reiko Inagi and
  • Tsutomu Ishikawa

Beilstein J. Org. Chem. 2018, 14, 3112–3121, doi:10.3762/bjoc.14.291

Graphical Abstract
  • carbonyl group at 4 position. Thus, it is generally difficult to synthesize the pentamethyl ether efficiently by conventional methylation. Here, we describe a simple and effective per-O-methylation of quercetin with dimethyl sulfate in potassium (or sodium) hydroxide/dimethyl sulfoxide at room temperature
  • results. Keywords: computational calculation; per-O-methylation; quercetin; quercetin pentamethyl ether; reactivity; Introduction Flavonoids are distributed widely in plants, and exhibit various biological activities [1]. Polymethoxyflavones (PMFs) in particular have attracted much attention due to
  • ][35][36], though 1 was smoothly obtained in other cases [37][38][39][40]. Therefore, we set out to re-examine the per-O-methylation of 2 in detail. In this paper, we describe a simple, practical and effective preparation of 1 from quercetin (2). A computational study of the methylation reactions of 2
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Published 28 Dec 2018
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