Templated versus non-templated synthesis of benzo-21-crown-7 and the influence of substituents on its complexing properties

• Wei Jiang and
• Christoph A. Schalley

Beilstein J. Org. Chem. 2010, 6, No. 14, doi:10.3762/bjoc.6.14

• intramolecular ring closure in the absence of phase-transfer catalysis, we synthesized the monotosylate 1 which is then used in a separate macrocyclization (Scheme 1). Disappointingly, only 24% yield was achieved for the synthesis of C7 from 1. A second fraction of 31% turned out to be a mixture of C7’s bigger